|I have not just two, or even three, but four ColdFusion instances all running in harmony with my Apache HTTP Server.
Leveraging the invaluable article by Brandon Purcell Installing and Configuring ColdFusion MX 6.1 Multiple Instances with IIS and Apache Virtual Hosts (and this works great with CFMX 7 too). I am happily providing web application isolation for all four web sites.
My multi-instance example: See it
Adding additional instances with CFMX 7 is even easier now:
CFMX 7 - Defining additional server instances
Here's a sample of my Apache httpd.conf (for brevity, this highlights only the critical elements):
Oh by the way, after you create new instances, running as services (for Windows Servers), you'll see that these instances may be named a bit odd. This is easily corrected with regedit as shown in the screenshot below: